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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'de340a25ba7dd458b57909c8d4229b4a29540d8d9abe4ff32fc224da0e80e21b' 
  AND token = 'RMtXEWzB9PPSBRS0/2NcyteqTxk4wTIvc9LadOqTpVQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}