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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43ee07321053ab71a1261400031713f063aac3eabcb0ba9e0dea9a7f56506fb0' 
  AND token = 'ph1a4aDY9AE1xm7tvFp/gIMjIjHKxAjHOTuL0PCYEXs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}