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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b72509bdc7b9092d5eb55fca173f0302cd0ee03271728ec1eee1a2fbe73aed4b' 
  AND token = 'yPUbtKm3f+RGKjOkMVseRnX7KxxvKLPdqwlJM9PkEgE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}