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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '546c508efabf4f0f52e6eecc72249d797bfa81d11406d2d598adfc9b0a22ba1f' 
  AND token = 'U9I2lxRTwyBNOpKCFv1RVYR+VIMmwmW2rFFmMDCWmVc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00056

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}