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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '645c4e8d9f10e5e76c4c1b7083c09381870b2e90b30d480146729d346d79f738' 
  AND token = 'fNyssSWC5v1ZGK9c4V4FzDNkOrXEfIXNUrxNWrFT44Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00064

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}