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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1858e49d6ea65694597fd100415970da146829dcf954fa9fbdb9f47d0e265656' 
  AND token = 'X6skTslz0Tj5byoYc+sqhtCGz1M7UKa1bQe8UZ/85+E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}