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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49c22b82c01a06035a4a53644b269c8090544ecbb64ba3d253d266cc51dc3217' 
  AND token = 'aMwsde8qKLaESqNnTE3VWlbfzNk3qgEW55GW2VRALxY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00052

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}