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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c43d032f73677bcc416dd312022539e365159fe037cb756020edbddcc1148e97' 
  AND token = '2DymtYUMOTER5e1MmT5ZAc4SAoYmXfXBZoPBZjqBJSU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}