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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2297f8f7e5f570a1f0760302e4e7f997ea8a574a2b07aed664d49315dd42f307' 
  AND token = 'TlAZx2csHJ+rIMTm9bPNHkM8WsP+KYGMVGiOyXU3D90=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}