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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5e353188a4e504f3e64c596145df891a9f035ff02c435022411f75c4e0484cf2' 
  AND token = 'uGuoqiS0BZoGDIAfK3zSOydYEpE2WRjVoPSXAM74m68=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}