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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '81b98162d4a41882e0751dbdab01b2ae58482ed3e687981f541234bbcbadb599' 
  AND token = 'GEM6FG5Jtw72IbzC1vwhD+L8rYye8DsNaxJCsMlYOMU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00064

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}