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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6c99351848214bfb74b16d1a2f41d568988dd2d45a4f9886ffd0cc5a209c5ae9' 
  AND token = 'vXtrSk0kgFIWvuLQUT0A7CUTcUqlaCNTh03Qps79ZAQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}