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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '378e2d0cc78472265f9b32f15eb82d31301014cced7bdf410903dc9a679aed38' 
  AND token = 'tlGJd0KN6uetHPh5tHEMTj/6/fuZPE4+btxtmGSy1xA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}