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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e4f4f18fe798339c966261e2eab1ae089fd8d357525b01f727821678c882bda3' 
  AND token = 'eSAXP6+1oUupGWM4oJQxMOSrYSMZt92aWlD8SH30HEk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}