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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '295990c75275bd36894befa335897fc7af9f0db0a5d1d8546781b590cf828271' 
  AND token = 'zGspxCWT5P4NuNGHieydvy/OmTx+c7rTMqx5MIVtcGM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}