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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5e95dfb155c0cf7176f21fca7282eba3a44cad14a145656fe1ea99a866344720' 
  AND token = 'AnYAR+i/EmrmNTjt23A0t9ZzV1iKLo6MPR/JCX7E8Zc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}