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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c0046870f684aa42037b6040b615e0df00f236d7865757b544029113d3dc19a1' 
  AND token = '1SS6U/QZVT1q2QCUDdVdcqAIelxTmHLqjoASYQvPHc0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}