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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3e1889c3b295f8f1f77f6dce396df2f1fa0c04f89ec073fd0d97eae50d94b228' 
  AND token = '53z9EYt6FZvExUTMCe8qGz7fgqhlmAc6zFuzvRrlTRw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}