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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b54656a3b46157e7e2912c7a476e521c68a87f8681dda839e11a8ba184fea3ee' 
  AND token = 'jzQhfsHCCiNNz68GY4h2ylWpLT2rMKB7UUfHzTDW0Dg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}