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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '748f3f511090a8541a7ec1a9177be8d5325c3a43202ae551225bf070158902d7' 
  AND token = 'ECl/G2I2CUK8hGVLz1xfFu6WvGBcld14uxtWLMsQX4Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}