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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a9b0b51db05d1a9630e6fb9e141bee7e58f7c853683e15c346837c6012349d2a' 
  AND token = 'U4Y6qGzMxaga6ki+xDK0yDuEr3sDht7sivl+ZnjkIRs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}