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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a48c633b4490d0cbff21bdf490266a7188bdd6ca86f415f2074a8965de298ff5' 
  AND token = 'lydzSd4R4b/qI0dAu+Gi7W8NsXmYtou0Mtp5kBgj/KE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}