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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e0e67643683905e4d9aa2d3206be9a008c7605dd4fe6d1729758b938352a375f' 
  AND token = 'mlDB3j0OyOWUEjKTW7rPIHpiFR5iqzR3JH8tdY3jFWM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}