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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '81461ed5f5b90fde4c32b572c4e35c5c312c045fac4326ceca21d80c8c41f833' 
  AND token = 'Ycfm24p+3l/6kzwh0FpB/tA71OO5gcR3nAI1B0zsObo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}