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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'bd68eff53a3ec1d386f73e810a15c84b378a3b46e252e203a55b7cb448a61814' 
  AND token = 'V2dwbX5TOH62S9VSY97BeOd/EYS+emoxNkbLlu5xLis=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}