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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '246fe58210dd7d4438efea268a7aeb260212cb7f78a18f9758b81b1c8c6b4d21' 
  AND token = 'gigP5zFIL3NFermQ8n6quSOSzw6cLXmGib8ZOVvqZGs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}