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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c8d3df9e5c72cc19f808b963590a0145f520d7576d703fdb950368edcd5bae85' 
  AND token = 'z9Z9ho0DoaXpOTXKH1ma+jwngNbsJM/3bxUl2K/XZL8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}