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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49d5d58747283f66f6aa6158d4dac1a4a3c2da5fcdea66674035c263ef370649' 
  AND token = 'h4Pu8xHf3HKS3UiNG9X6QzOszBP3ydrs0hyRLXBXvM8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}