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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8ce437d0c61e7db642f872a26308428c9967d60e45518d02567c0616a9aa8365' 
  AND token = 'ZdGKSQJlRHIfRIKtyn/pZfZ6vM3+FrzIm4Xr29TmRNI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}