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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '00a387b796b9410fdd830bda0b6c2cdfe7d2504955ab4ea9841b9025a2771057' 
  AND token = '8Dw0/IfMxcuPeLWh9+E4eRQXROA+EY4GGKmqxfBt7Z8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00050

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}