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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3f8ad330b40e99493286e2a2487f19d0d206603c2a3b178f31c3bb1858d0e3bf' 
  AND token = 'iYnBFA1p2UzrKd5UEw9Qktftc8BxbTOx6LbEMD6Ojm0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}