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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'df12ca0c276f8c386bee3a07e71be0ba7d895980258da65c37e4a0eed1c02f38' 
  AND token = 'BHTj0H4y99rdUPyEHz5XbC1C5sjUmtlLztSdfZ2z22s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00049

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}