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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2a19f55c924db5fdd904883132f7c3159e45e16008ebd52835c6023387a169e4' 
  AND token = 'TuDy5oDvRzzAFT+pmEkEgWHRBMZYCsxA5wKDy1bd/M4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}