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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78a23acf00c31a83136b74bce7bbb644c2a6b95223d42944f7606b9b7661afb0' 
  AND token = '8SMurPbzLyD5UliDyhxrjEnYvEHacit3/JUbvXh3XVY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}