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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ff381d21af806e1559127e0c8b4592072b277a1f67c587c153fc02226703963d' 
  AND token = '2QX/sCZrBtGYQECK9x4vxggNv6ef7MbkcKQXNieAjjI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}