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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6bdf3feb9a86f0388ecad3010489e1ca337fb5df0e71b6b6349c2bc06846a6c1' 
  AND token = 'Kq3GFjMH/scmZsfbFkLpVlEwMp7Ujo6MhIiScQ4/fS0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}