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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd4161b642b8a012b3790d782033184046474b79b1c93aadb75463d76d5649d7b' 
  AND token = 'xlQYxSEKK7GcdmWI4zsIiLfImNe4cAT4erMAyEUr5wM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}