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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '29c80e394f24666508a6032a27e1ff21ba0b2361baa3331e1a95fced9c3c4df6' 
  AND token = 'I8MTmyizPlQLF7ZadPbD+SMQqBYftDyw6IHz84Y/Nis=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}