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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c1b10007b82e93a09293b82225e7653af257b4e5bc96a42f6d6af224cc2b18d6' 
  AND token = 'RE/CRpBrS7B3hTCSF3l1x0fgYi/5LP05teyOu2zYOPg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}