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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '48693d8e9b463dc1435e8a89302a7d33654d888c8cd2df553f6ae67e8ace877b' 
  AND token = 'HVVr0AZMh2RUEai9GWKmWRwzsdhr7NLBaQ5qCZ1N/U4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}