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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cc681d2217d76bbf6631a2069f367609045026fb99e20e3f1e3d1a6103426acf' 
  AND token = 'HF2RRM7uhF+RMG+VkPjHSC3IjOGgwDL+lRmfaV6nhho=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}