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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '00c50c69be0585c50ed0b462a3bfb00b9a10568c369313b566bb2adaa391f415' 
  AND token = '4UJDNvGs45A9QFdpKQN7+xAAnHLgkUE2VMLFPC5FGwE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}