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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '180b08ec1bbd496481b755f79ef90b7e7fa50fdc6dbd84a5870607b9c0df4d15' 
  AND token = '0ZWP4/tE6QcMplkc9zkPmEuFWy7xIywMOBuq/VFMvXY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}