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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '081650b9247d148698a60c8e861b63f77c56c2135a3a9b2a97c2e07657cc0917' 
  AND token = 'HGaSyfWjOWc8/Pj2swX4x7ytqsFh3E4zTjEFC0c7sc4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}