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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49495e0b5d44dacc160087d784d0461441d3dd2e09c31171ac0aab508ae23e56' 
  AND token = 'nrdsPQAsEK6yqgDmgT4iw/ETMX/9DnMfE9k4BfR4ZUA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}