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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '42648a90e93a304a171b88a7986f2987971a6f7cab4c4d44a1e34c211a8e9f52' 
  AND token = 'OPn9SWL0VzzOVP0pk/ZKOLerUtt9odDPhL5JyQDSV1s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}