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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '25360b4449d944825ff7e1e2e7cdc8b321d614fe12eb64724994e9c6641aaa9b' 
  AND token = '5FQZ/r4S7g4SUGlIhD0vhLJKcQxEfAGdb7vMOvP0Xp0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}