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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '48307b08261faff0fe6561dfdc32296b52f38d806f6f8335dbc3b27f9979db3a' 
  AND token = '64zgANhl+dV6qFvrfTgjT41W+O7OlmkZFz7kI2rX+3M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}