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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5a1a8194d6b86dd3d45645d3c2f3921f2f23a1bace159b971343876ffdad6aab' 
  AND token = 'VT8fDXPfr8D0Cbdo1AD+285XQk91gCZbMZiedLb9/jk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}