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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21096103503080766e905b33b585bc769b1fb4a5a90fd6d24dab8b8ef3ed00e5' 
  AND token = 'twKV77wj/Qa9whqHOrB/MM4SPyR343tpSmXDbRMA81Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}